Calmoseptine Ointment was originally developed by a pharmacist for use as a diaper rash ointment for infants. Since its introduction 80 years ago, many other uses have been found. The following list has been compiled from feedback from doctors, nurses and other health care professionals who have used Calmoseptine Ointment. Diaper Rash in Full-Term Infants through Adults. Skin Protection in Incontinent Adults. Relieves Pain and Helps Promote Healing. Skin Protection around Feeding and Drainage Tube Sites.